Non-cognate CD8 Binding to MHC I Promotes Positive Selection of an MHC-E Restricted CD8 T Cell Population - PubMed
a day ago
- #CD8 T cells
- #T cell development
- #MHC-E
- MHC-E-restricted CD8 T cells have strong protective capacity and therapeutic potential.
- Thymic development of QFL T cells (reactive to FL9 peptide presented by Qa1b) was studied under ERAAP deficiency.
- QFL T cells can develop without Qa1b but require classical MHC Ia for positive selection.
- Non-cognate CD8-MHC Ia interactions enhance responses to MHC Ib ligands in QFL thymocytes.
- H2-T11, an MHC Ib molecule, was identified as an alternative ligand for the QFL TCR.
- Both cognate and non-cognate MHC interactions contribute to Qa1b-specific T cell development.