The E3-ome gene-centric compendium reveals the human E3 ligase landscape - PubMed
3 hours ago
- #disease research
- #E3 ubiquitin ligase
- #bioinformatics
- The E3-ome compendium identifies 672 high-confidence E3 ubiquitin ligases (E3s) in the human genome.
- It integrates experimental data, bioinformatics, and published research to standardize E3 classifications.
- The study reveals previously unrecognized domains, motifs, and E3 candidates, expanding E3 diversity.
- Spatial and physiological mapping of E3s across tissues and cell types shows context-dependent roles.
- Genetic analyses link E3s to diverse human pathologies, aiding disease research.
- Multiple authors have financial interests or advisory roles in biotech and pharmaceutical companies.