Cytoplasmic lattices are megadalton storage complexes in mammalian oocytes - PubMed
2 hours ago
- #cytoplasmic lattices
- #maternal effect factors
- #oocyte protein storage
- Cytoplasmic lattices (CPLs) are megadalton storage complexes in mammalian oocytes.
- CPLs store proteins essential for early embryonic development.
- The molecular composition includes at least 13 proteins, including maternal effect factors like PADI6 and the subcortical maternal complex.
- Structural components include α- and β-tubulin dimers and ubiquitination factors like UHRF1, E2 enzymes, and adaptors.
- CPLs provide a mechanism for stockpiling proteins through stable supramolecular assemblies.
- Understanding CPLs helps explain infertility and developmental defects due to disrupted maternal factors.