Gsα deficiency in macrophages promotes tumor progression via the MAPK signaling pathway - PubMed
5 hours ago
- #TAMs
- #Gsα
- #MAPK
- Gsα deficiency in tumor-associated macrophages (TAMs) accelerates tumor growth and metastasis in B16 and MC38 tumor models.
- Gsα upregulates CD86, CCR5, Il1b, and Nos2 while inhibiting CD206 and Il10, enhancing antitumoral activity of TAMs.
- Gsα promotes proinflammatory M1-like polarization of TAMs by increasing phosphorylation of ERK, p38, and JNK in the MAPK signaling pathway.
- The study suggests Gsα-deficient TAMs exhibit protumoral activity via the MAPK pathway, indicating a potential target for cancer immunotherapy.