Gut microbiota and SCFA biomarkers for early diagnosis of PD patients and differentiation of its motor subtypes - PubMed
19 hours ago
- #gut microbiota
- #Parkinson's disease
- #SCFA biomarkers
- The study analyzed gut microbiota and SCFAs in early drug-naïve PD patients, ET patients, and healthy controls to find diagnostic biomarkers.
- Compared to healthy controls, PD patients showed reduced Citrobacter and Haemophilus, increased Eggerthella, and elevated isovaleric and isobutyric acids, with a validation AUC of 0.864.
- PD versus ET was distinguished by decreased Bilophila, Bacteroides, and Haemophilus with elevated isovaleric, isobutyric, and valeric acids, achieving a validation AUC of 0.825.
- Tremor-dominant PD (TD-PD) differed from ET by lower Lachnoclostridium, Haemophilus, and Bilophila and higher isovaleric and isobutyric acids, with a validation AUC of 0.780.
- Non-TD-PD was differentiated from TD-PD only by decreased Dialister, resulting in a validation AUC of 0.802.
- Gut microbiota and SCFAs may serve as specific, non-invasive candidate biomarkers for early PD diagnosis and motor subtype differentiation.