Tissue Penetration of Gemcitabine and Gemcitabine Phosphate Metabolites Following Gemcitabine Intravesical System Administration Versus Standard Intravesical Instillation in a Preclinical Minipig Mode
4 hours ago
- #Bladder cancer
- #Drug delivery
- #Gemcitabine
- Gemcitabine intravesical system (gem-iDRS) provides prolonged local gemcitabine delivery compared to standard intravesical instillation.
- Traditional gemcitabine instillation shows active metabolites in bladder layers at 2 hours but undetectable by 24 hours.
- gem-iDRS maintains measurable metabolite levels across bladder regions for at least 96 hours.
- Study conducted on minipigs, limiting generalizability to tumor-bearing bladder tissue.
- Findings suggest gem-iDRS enhances bladder tissue exposure duration over traditional methods.