Chinese Herbal Medicine in Ulcerative Colitis-Associated Carcinogenesis Treatment: Mechanisms, Progress, and Future Directions - PubMed
4 hours ago
- #ulcerative colitis associated carcinogenesis
- #gut microbiota
- #traditional Chinese medicine
- Colitis-associated colorectal cancer (CAC) is a prevalent malignancy linked to ulcerative colitis (UC), making its prevention crucial.
- Traditional Chinese medicine (TCM) interprets UCAC through theories like 'dampness-heat stasis' and 'latent pathogen-induced deficiency'.
- This review analyzes about 79 studies (2020-2025) on TCM's clinical applications, including oral/topical herbal therapies and acupuncture for UCAC prevention and treatment.
- Mechanisms of TCM interventions focus on gut microbiota modulation and inflammatory pathways such as NF-κB and IL-6/JAK2/STAT3.
- It offers a novel systematic synthesis of TCM therapeutic methods and molecular mechanisms for UCAC, bridging TCM theories with modern medical perspectives.
- A proposed integrated 'gut microbiota-metabolite-target' research framework aims to modernize TCM and develop combined therapeutic strategies with Western medicine.