Downregulated lysyl oxidase in plasma extracellular vesicles: a biomarker linked to brain metastasis risk in lung adenocarcinoma - PubMed
7 hours ago
- #Biomarker
- #Lung Adenocarcinoma
- #Brain Metastasis
- Downregulated lysyl oxidase (LOX) in plasma extracellular vesicles (EVs) is linked to brain metastasis (BrM) risk in lung adenocarcinoma (LUAD).
- A multi-omics approach identified LOX as a key biomarker, showing consistent downregulation in BrM tissues and plasma EVs.
- Single-cell analysis revealed decreased LOX expression in BrM-associated fibroblasts, suggesting a role in ECM degradation and metastasis.
- Plasma EV-derived LOX demonstrated strong diagnostic performance (AUC 0.786) in an independent cohort, validating its potential as a non-invasive biomarker.
- The study proposes a PI3K/AKT-LOX-ECM regulatory axis, offering insights for risk stratification and intervention in LUAD patients.