Delactylation of viral proteins by SIRT1 suppresses influenza A virus replication - PubMed
3 hours ago
- #influenza A virus
- #lactylation
- #SIRT1
- SIRT1 suppresses influenza A virus (IAV) replication by delactylating viral proteins.
- IAV infection downregulates SIRT1 expression, enhancing viral replication.
- SIRT1 interacts with IAV NP, PA, PB1, and PB2 proteins, inhibiting vRNP complex activity.
- Viral proteins NP, PA, PB1, and PB2 undergo lactylation during IAV infection.
- SIRT1 promotes delactylation of NP, PA, and PB2, reducing IAV replication.
- Inhibition of lactate dehydrogenase A (LDHA) reduces lactylation of viral proteins, counteracting SIRT1 deficiency effects.
- Findings highlight lactylation's role in regulating IAV infection and pathogenesis.