The ISR downstream effector ATF4 promotes mGluR-dependent long-term depression and associated behavior - PubMed
2 days ago
- #ATF4
- #mGluR-LTD
- #synaptic plasticity
- The integrated stress response (ISR) modulates synaptic plasticity, including long-term depression (LTD).
- Activation of group I mGluRs increases ATF4 protein levels and downregulates oxidative phosphorylation (OXPHOS) proteins.
- Deletion of ATF4 in excitatory neurons impairs mGluR-LTD and disrupts object-place learning.
- ATF4 regulates synaptic plasticity by modulating mitochondrial function.
- A small molecule inhibitor of OXPHOS rescues impaired mGluR-LTD in ATF4-depleted neurons.