Per- and Polyfluoroalkyl Substances During Pregnancy and Gestational Diabetes: The Environmental Influences on Child Health Outcomes (ECHO) Cohort - PubMed
4 hours ago
- #pregnancy
- #PFAS
- #gestational diabetes
- Study examines the association between PFAS exposure during pregnancy and gestational diabetes mellitus (GDM).
- Participants included 5,229 women from 16 U.S. cohorts with singleton pregnancies (1999-2021).
- Six PFAS detected in ≥60% of participants were analyzed for associations with GDM and fasting glucose.
- Primary outcome was GDM diagnosis; secondary outcome was fasting glucose in a subset of 1,213 participants.
- Associations between individual PFAS and GDM were null or weakly inverse.
- The six-PFAS mixture showed a negative association with GDM (prevalence ratio per quartile increase: 0.75).
- Stronger negative associations were observed in participants with BMI <25 kg/m².
- Associations between PFAS and fasting glucose were largely null, with some variations by race and ethnicity.
- Conclusion: Higher PFAS concentrations were not associated with increased GDM prevalence in this large U.S. cohort.