Molecular mechanisms of Klebsiella pneumoniae pathogenicity: from virulence factors to emerging therapeutic strategies - PubMed
4 hours ago
- #Klebsiella pneumoniae
- #anti-virulence therapy
- #hypervirulence
- K. pneumoniae is a major global health threat linked to neonatal sepsis, childhood mortality, and antibiotic-resistant infections.
- Hypervirulent strains (hvKP) with carbapenem resistance have been detected worldwide, leading to a formal WHO warning.
- The mechanisms behind K. pneumoniae's pathogenicity, including virulence factors and immune evasion, are not fully understood.
- This review covers virulence factors, immune evasion, phenotypic plasticity, and explores anti-virulence therapeutic strategies.