The Multi-target Cardiac Protection Mechanism of Butylphthalide and AI-driven Precision Medicine: from Molecular Basis to Clinical Translation - PubMed
3 hours ago
- #Cardioprotection
- #AI in medicine
- #Butylphthalide
- Butylphthalide (NBP) is a lipophilic small-molecule drug with multi-target properties, originally used for ischemic stroke and now showing cardiac protective effects.
- Its mechanisms include antioxidant, anti-inflammatory, anti-apoptotic actions, and maintenance of mitochondrial function, calcium regulation, and anti-fibrotic effects.
- AI and systems pharmacology enhance research via network pharmacology, multi-omics, virtual screening, and digital twins to study mechanisms and individual variability.
- AI-driven approaches are expected to support personalized cardiac protection therapy, representing a 'drug + intelligence' integration model for cardiovascular drugs.