Exploring the Potential Mechanism of Polyethylene Terephthalate Associated Cardiotoxicity through Network Toxicology and Molecular Docking - PubMed
8 hours ago
- #Polyethylene Terephthalate
- #Cardiotoxicity
- #Computational Toxicology
- Study explores cardiotoxicity mechanisms of polyethylene terephthalate (PET) using computational methods.
- PET monomers (TPA and EG) interact with cardiac-related proteins, potentially causing cardiomyopathy.
- Network toxicology, molecular docking, and dynamics simulations identify key protein interactions.
- Core targets linked to cardiomyopathy subtypes (HCM, DCM, ICM) were analyzed.
- Pathways affected include cGMP-PKG signaling, insulin resistance, and lipid metabolism.
- Molecular docking shows stable interactions with ERBB2 and GSK3β proteins.
- Findings suggest PET exposure may disrupt cardiac pathways, warranting further toxicological studies.