Lactate-induced metabolic reprogramming of TAMs impairs antigen presentation capacity via C/EBPα-CD74 axis in oral squamous cell carcinoma - PubMed
3 days ago
- #oral squamous cell carcinoma
- #tumor-associated macrophages
- #CD74
- Lactate accumulation in the tumor microenvironment (TME) induces metabolic reprogramming of tumor-associated macrophages (TAMs).
- This reprogramming drives acetylation of C/EBPα, leading to suppression of CD74 expression in TAMs.
- Downregulation of CD74 impairs the antigen-presenting capacity of TAMs and suppresses T cell activation.
- The lactate-C/EBPα-CD74 axis plays a critical role in promoting oral squamous cell carcinoma (OSCC) progression and recurrence.
- CD74-high TAMs decrease during OSCC progression and are associated with patient prognosis.
- The study provides potential therapeutic targets for OSCC immunotherapy.