H3K56 lactylation promotes collagen II synthesis to modulate chondrocyte metabolism in posttraumatic osteoarthritis - PubMed
3 hours ago
- #chondrocyte
- #collagen II
- #osteoarthritis
- H3K56 lactylation promotes collagen II synthesis in chondrocytes.
- Histone lactylation is mediated by lactate and regulates chondrocyte functions.
- The study investigates the role of H3K56la in modulating type II collagen synthesis.
- HIF 1α expression is upregulated by histone lactylation.
- HIF 1α knockdown reduces H3K56 lactylation and Col2a1 expression.
- H3K56la and HIF 1α synergistically regulate collagen synthesis.
- HIF 1α binds to the Col2a1 promoter to enhance transcription.
- α-ketoglutarate treatment increases H3K56la and Col2a1 expression.
- The lactate/H3K56la/HIF 1α axis is a potential therapeutic target for posttraumatic osteoarthritis.