Immunodominance is a poor predictor of vaccine-induced T follicular helper cell quality - PubMed
4 hours ago
- #Vaccine
- #T follicular helper cells
- #Immunodominance
- Immunodominance is not a reliable predictor of vaccine-induced T follicular helper (TFH) cell quality.
- Rational engineering of vaccine immunogens can exclude critical CD4+ T cell epitopes, compromising immunogenicity.
- Priming of naïve CD4+ T cells is efficient, but immunodominance does not predict the quality of B cell help.
- A single MHC class II epitope can drive robust germinal center responses and serum IgG titres.
- Not all CD4+ epitopes provide equivalent B cell help, despite priming similar numbers of CD4+ T cells.
- Multimerizing and arraying antigens on nanoparticle scaffolds can enhance subdominant CD4+ T cell helper responses.
- The study highlights the importance of CD4+ T cell help for durable humoral immunity and vaccine design.