Integrating chronic inflammation and hypoxia: the potential role of HIF-1α in tumor behavior and therapy response in high-grade serous ovarian cancer - PubMed
6 hours ago
- #ovarian cancer
- #chemoresistance
- #HIF-1α
- HIF-1α expression varies spatially in HGSOC, with higher levels in omental and peritoneal tissues versus ovarian tissue.
- Elevated HIF-1α in ascites and plasma at baseline correlates with ESR >30 mm/h and poor chemotherapy response (CRS1).
- Increased peritoneal HIF-1α at baseline shows a trend toward shorter progression-free survival.
- The hypoxic-inflammatory microenvironment in HGSOC appears persistent despite chemotherapy, potentially driving chemoresistance and progression.