The gut microbiota alleviates depression by remodeling gut-brain energy metabolism - PubMed
3 hours ago
- #gut microbiota
- #energy metabolism
- #depression treatment
- Elevated fecal creatine and reduced creatine in plasma and cerebrospinal fluid are observed in depression patients and mouse models.
- Exogenous creatine has antidepressant-like effects, mediated by gut microbiota, specifically Bifidobacterium pseudolongum.
- Bifidobacterium pseudolongum supplementation enhances creatine's antidepressant effects by promoting creatine transporter expression via acetate.
- Neuronal creatine deficiency affects energy metabolism and neurophysiological function in depression.
- Creatine and Bifidobacterium co-administration in patients increases plasma creatine levels and reduces depression scores.