Neurons with granulovacuolar degeneration bodies are resilient to tau-induced protein synthesis impairment - PubMed
4 days ago
- #Alzheimer's disease
- #neuronal resilience
- #tau pathology
- Neurons with granulovacuolar degeneration bodies (GVBs) show resilience to tau-induced protein synthesis impairment.
- Casein kinase 1δ (CK1δ) activity is essential for GVB formation, with CK1δ being sequestered in GVBs in an autophagy-dependent manner.
- GVB+ neurons are protected against tau-mediated neurodegeneration and maintain the capacity for long-term potentiation-induced protein synthesis despite tau pathology.
- GVB+ neurons exhibit increased ribosomal content but do not show differential activation of transient translational stress responses.
- CK1δ is identified as a key regulator of GVB formation, offering a protective neuron-specific stress response to tau pathology.
- These findings suggest potential therapeutic targets for enhancing neuronal resilience in tauopathies.