Conjugated bile acids facilitate cholangiocyte senescence to promote cholestatic liver diseases via STING signaling - PubMed
3 hours ago
- #STING signaling
- #cholestatic liver disease
- #cholangiocyte senescence
- Conjugated bile acids and STING signaling play a key role in cholestatic liver diseases.
- STING activation correlates with liver injury severity in PBC, PSC, BDL, and Abcb4-/- mice.
- Tmem173-/- mice showed protection against cholestasis-induced ductular reaction, inflammation, and fibrosis.
- Conjugated bile acids induce mitochondrial damage in cholangiocytes, leading to oxidized DNA leakage and SASP via STING activation.
- Cholangiocyte SASP promotes macrophage infiltration and activation, further driving inflammasome activation and pyroptosis.
- STING signaling is identified as a promising therapeutic target for cholangiopathies.