Ectopic B lymphocyte follicles exacerbate ischemic brain damage via MIF-CD74/CXCR4 and interferon signaling - PubMed
4 hours ago
- #Ischemic stroke
- #Neuroinflammation
- #B cells
- Ectopic B lymphocyte follicles worsen ischemic brain damage via MIF-CD74/CXCR4 and interferon signaling.
- B lymphocytes accumulate in ischemic lesions, forming germinal center-like structures post-stroke, primarily through in situ proliferation.
- B cell depletion reduces chronic brain damage during stroke.
- Microglia recruit B cells into ischemic lesions via MIF-CD74/CXCR4 signaling in the early phase of stroke.
- IFN-related pathways in B cells drive neuroinflammation and brain injury.
- Targeting MIF-CD74/CXCR4 and IFN pathways alleviates cerebral ischemia and inflammation.
- Findings highlight B lymphocytes' role in stroke pathology and suggest new therapeutic interventions.