Current and Developing Therapeutics for Dry Eye Disease: Targeting Ion Channels - PubMed
7 hours ago
- #dry eye disease
- #neuropathic ocular pain
- #ion channels
- Dry Eye Disease (DED) is a multifactorial ocular disorder with tear film instability, inflammation, epithelial damage, and neurosensory abnormalities.
- Current treatments (artificial tears, anti-inflammatory drops, systemic neuromodulators) often fail to address neuropathic ocular pain.
- Recent research highlights ion channels, such as TRP, Nav, and P2X receptors, in mediating ocular surface homeostasis, pain signaling, and inflammation.
- Ion channels respond to environmental stimuli like heat, cold, osmolarity, and injury, contributing to DED pathophysiology.
- Emerging therapies targeting sensory transduction pathways offer potential for personalized treatment, especially for neuropathic features unresponsive to standard care.