Different exercise modalities and their effects on the inflammatory mediator repertoire in breast cancer survivors: A systematic review with Bayesian network meta-analysis and dose-response analysis -
4 hours ago
- #exercise-therapy
- #inflammation
- #breast-cancer
- The study compares effects of different exercise modalities on inflammatory mediators in breast cancer survivors.
- Exercise modalities evaluated include aerobic exercise (AE), resistance training (RT), combined exercise (CE), and low-intensity exercise (LA).
- A systematic review and network meta-analysis of 27 RCTs involving 1925 participants was conducted.
- Primary outcomes measured were IL-6, TNF-α, HSCR-P, IL-8, and IL-10 levels.
- Combined exercise (CE) was most effective in reducing IL-6, IL-8, and TNF-α.
- Aerobic exercise (AE) was most effective in reducing HSCR-P, while low-activity exercise (LA) increased IL-10.
- Subgroup analyses showed variations in biomarker responses by age and exercise dose.
- Dose-response analysis suggested optimal weekly doses for inflammation control range from 510 to 920 MET-minutes.
- Combined exercise (CE) offers the most comprehensive anti-inflammatory benefits.
- Tailoring exercise prescriptions by age and hormonal status may enhance efficacy and safety.