Single-nucleus epigenomic profiling of the adult human central nervous system unveils epigenetic memory of developmental programs - PubMed
5 hours ago
- #epigenomics
- #oligodendroglia
- #central nervous system
- Single-nucleus epigenomic profiling reveals transcriptional heterogeneity in the adult human CNS.
- Epigenetic signatures in adult oligodendroglia (OLG) and astrocytes resemble developmental profiles but are decoupled from gene expression.
- A putative SOX10 enhancer and primed chromatin signatures at HOX loci were identified in spinal-cord-derived OLG and astrocytes.
- Micro-C analysis shows induced pluripotent stem-cell-derived OLGs share HOX chromatin architecture with adult OLGs and high-grade pontine gliomas.
- Epigenetic memory in adult OLG facilitates Hox gene transcription during regeneration and increases susceptibility to gliomagenesis.