Lysosome-targeting live attenuated influenza vaccines elicit robust and broad immunity in mice - PubMed
3 hours ago
- #live attenuated vaccine
- #lysosome-targeting
- #influenza vaccine
- Lysosome-targeting live attenuated influenza vaccines (LYTAR 1.0 and LYTAR 2.0) were developed to conditionally degrade viral proteins.
- These vaccines maintain replication efficiency similar to wild-type virus in producer cells but are attenuated in conventional cells.
- In mouse models, the vaccines induced strong, broad immune responses and provided cross-reactive protection against H1N1 and H3N2 influenza strains.
- The study presents a new platform for developing safe and effective live attenuated vaccines.