Interplay Between Exosomes and the PD-1/PD-L1 Axis in Hepatocellular Carcinoma: Implications for Immune Escape and Immunotherapy - PubMed
4 hours ago
- #Immunotherapy
- #HCC
- #Exosomes
- Exosomes play a key role in the immunosuppressive tumor microenvironment of hepatocellular carcinoma (HCC).
- Exosomal PD-L1 contributes to immune evasion by maintaining T-cell exhaustion and causing resistance to immune checkpoint inhibitors (ICIs).
- Various exosomal cargoes in HCC, including microRNAs and non-coding RNAs, enhance PD-L1 expression and promote immune dysfunction.
- Certain immune-cell-derived or engineered exosomes can counteract immunosuppression, offering potential therapeutic strategies.
- Circulating exosomal biomarkers like PD-L1 and specific lncRNAs show predictive value for ICI response in HCC.
- Targeting exosome-mediated immunosuppression could lead to more effective immunotherapies for HCC.