The role of non-coding RNAs in exosome-mediated wound healing: A systematic review and meta-analysis - PubMed
4 hours ago
- #Noncoding RNA
- #Wound Healing
- #Exosomes
- Non-coding RNAs (ncRNAs) in exosomes show promise for wound healing, especially in chronic wounds like diabetic foot ulcers.
- A systematic review and meta-analysis of 44 preclinical studies found exosomal ncRNA significantly improves wound closure rates (SMD = 2.89).
- Subgroup analysis revealed long non-coding RNAs (lncRNAs) had the largest effect (SMD = 3.72), followed by microRNAs (miRNAs) and circular RNAs (circRNAs).
- Secondary outcomes like angiogenesis, collagen deposition, re-epithelialization, and scar width reduction also showed significant improvements.
- The study suggests exploring specific ncRNA classes for targeted therapeutic approaches in wound healing.