Exploring the causal link between long-term elevated plasma caffeine levels and age-related eye diseases using Mendelian randomization - PubMed
3 hours ago
- #eye diseases
- #caffeine
- #Mendelian randomization
- Long-term elevated plasma caffeine levels reduce risks of dry AMD, wet AMD, age-related cataract, and primary open-angle glaucoma.
- Approximately half of the protective effect on primary open-angle glaucoma is mediated through intraocular pressure reduction.
- Mendelian randomization analysis used genetic variants near CYP1A2 and AHR genes as instrumental variables.
- The study provides novel evidence using fasting plasma caffeine levels for accurate exposure assessment.