Physical Fitness Is Negatively Associated With DNA Methylation-Based Risk of Aging-Related Diseases - PubMed
4 hours ago
- #Physical Fitness
- #Aging Diseases
- #DNA Methylation
- Physical fitness traits (VO2max, grip strength, jump performance, BMI, cognition) are linked to DNA methylation-based protein level estimates (EpiScores) in a cohort of 290 mostly older individuals.
- Higher BMI is associated with increased risk for diseases like diabetes, stroke, heart disease, lung cancer, COPD, IBD, and depression, but lower risk for rheumatoid arthritis.
- Cognitive fitness shows negative associations with rheumatoid arthritis, depression, and COPD, while grip strength and jump performance are negatively linked to diseases such as diabetes and COPD.
- A workflow using DNA methylation and fitness measurements can evaluate patient-level disease risk, validated by correlations with an independent CVD EpiScore benchmark.
- The study highlights EpiScores as molecular markers for early disease risk stratification and personalized prevention of aging-related diseases.