Bridging the Scales via Personalized Cellular Modeling and Deep Phenotyping in Schizophrenia - PubMed
7 hours ago
- #synaptic dysfunction
- #personalized modeling
- #schizophrenia
- The study explores how synaptic dysfunction in schizophrenia translates to neural circuit issues and cognitive deficits.
- It uses patient-derived neurons to connect gene expression and synapse density with brain structure, electrophysiology, and cognition in 461 participants.
- Findings show gray matter reductions in specific regions and gamma band disturbances are linked to cognitive impairments in schizophrenia.
- Individual differences in neuronal gene expression and synapse density predict structural, electrophysiological, and cognitive changes in vivo.
- The research establishes a multiscale framework for personalized understanding, aiding in mechanism-based stratification and precision treatments for cognitive impairment.