miR-7480-5p/SIRT3/GSH axis mediates selenium Deficiency-Exacerbated trimethyltin chloride-induced ferroptosis in chicken thymus - PubMed
4 hours ago
- #Selenium Deficiency
- #Ferroptosis
- #Mitochondrial Stress
- The study investigates the combined effects of selenium deficiency (SeD) and trimethyltin chloride (TMT) exposure on poultry thymus toxicity.
- Both SeD and TMT individually and together cause thymic structural abnormalities, mitochondrial oxidative stress, mitophagy, and ferroptosis.
- The miR-7480-5p/SIRT3/GSH axis is identified as a key regulator of mitochondrial quality control and ferroptosis in this context.
- Combined exposure to SeD and TMT results in more severe damage compared to individual exposures.
- Findings provide new insights into mechanisms of TMT-induced toxicity in selenium-deficient conditions and suggest potential intervention targets.