A nature-inspired nanoplatform for multi-protein targeted degradation via the autophagy-lysosome pathway - PubMed
3 hours ago
- #targeted degradation
- #extracellular vesicles
- #autophagy
- EVs are primarily degraded via the lysosomal pathway, involving MAP1LC3B recognition of SNX18 on EVs.
- An EV-based nanoplatform was developed with surface LIR motifs to enhance lysosomal sorting efficiency for targeted protein degradation.
- This modular nanoplatform effectively degrades EGFR, PD-L1, and VEGF, and can simultaneously target multiple proteins like EGFR and VEGF.
- The study reveals a new mechanism for EV degradation and offers a nature-inspired strategy for multi-protein targeted degradation.