Large-scale proteomics across neurological disorders uncovers biomarker panel and targets in multiple sclerosis - PubMed
4 hours ago
- #biomarkers
- #multiple sclerosis
- #proteomics
- Large-scale proteomics study analyzed cerebrospinal fluid (CSF) from 5,000 individuals across neurological disorders.
- Identified proteomic alterations linked to blood-CSF barrier impairment, age, and sex.
- Focused on multiple sclerosis (MS), deriving a 22-protein biomarker panel that outperformed existing markers.
- Validated the panel in an independent cohort using targeted mass spectrometry.
- Highlighted proteins of therapeutic interest and demonstrated proteome-based staging of MS progression.
- Study involved high-throughput mass spectrometry, quantifying up to 2,100 proteins per sample.