Association between urinary polycyclic aromatic hydrocarbon metabolites and sleep disturbances: A cross-sectional study integrating machine learning and network toxicology - PubMed
4 hours ago
- #polycyclic aromatic hydrocarbons
- #machine learning
- #sleep disturbances
- Study investigates the association between urinary polycyclic aromatic hydrocarbon (PAH) metabolites and sleep disturbances.
- Data from 3,262 adults (≥20 years) from the National Health and Nutrition Examination Survey (2005-2012) was analyzed.
- 11 machine learning algorithms were used, with Random Forest and CatBoost identifying key pollutants: 1-hydroxypyrene, 2-hydroxyfluorene, 3-hydroxyfluorene, and 3-hydroxyphenanthrene.
- Network toxicology and molecular docking identified critical protein targets: androgen receptor, B-cell lymphoma, nuclear receptor subfamily 3 group C member 1, and transient receptor potential vanilloid 1.
- Findings suggest a link between PAH metabolites and sleep disturbances, providing a basis for future preclinical studies and interventions.