Sodium Butyrate Alleviates IBD by Modulating SIRT1-Involved Ferroptosis and Inhibition of Macrophage Ferroptosis - PubMed
3 hours ago
- #IBD
- #SIRT1
- #ferroptosis
- Sodium butyrate (NaB) alleviates inflammatory bowel disease (IBD) symptoms in mice.
- NaB modulates SIRT1-associated signaling molecules to inhibit ferroptosis.
- NaB downregulates ACSL4 and upregulates GPX4 and SLC7A11, indicating ferroptosis inhibition.
- Immunofluorescence staining shows increased GPX4 expression in macrophages with NaB treatment.
- The study suggests NaB's potential as a therapeutic agent for IBD by targeting ferroptosis pathways.