Catheter Ablation and Oral Anticoagulation for Secondary Stroke Prevention in Atrial Fibrillation: The STABLED Randomized Clinical Trial - PubMed
3 hours ago
- #Atrial Fibrillation
- #Catheter Ablation
- #Stroke Prevention
- The STABLED trial evaluated catheter ablation added to standard therapy for reducing recurrent stroke in atrial fibrillation patients with recent stroke history.
- Patients were randomized to standard therapy or standard therapy plus catheter ablation, with follow-up over 3 years.
- Primary endpoint included recurrent ischemic stroke, systemic embolism, all-cause death, and hospitalization for heart failure.
- No significant reduction in primary composite endpoint was observed with catheter ablation compared to standard therapy alone.
- Event rates were lower than anticipated, suggesting the study may have been underpowered to detect meaningful differences.
- Safety assessments reported two ablation-related adverse events (cardiac tamponade and stroke), each at 0.8%.