A protein disulfide isomerase coordinates redox homeostasis and ER calcium regulation for optimal lytic cycle progression in Toxoplasma gondii - PubMed
10 hours ago
- #calcium homeostasis
- #Toxoplasma gondii
- #protein disulfide isomerase
- A protein disulfide isomerase, TgPDIA3, is studied for its role in coordinating redox homeostasis and ER calcium regulation in Toxoplasma gondii.
- The endoplasmic reticulum (ER) supports protein folding through disulfide bond formation, facilitated by PDIs, which include conserved CXXC motifs.
- T. gondii, infecting about one-third of the global population, has a lytic cycle driven by calcium signaling, with the ER being a key calcium reservoir.
- The research uncovers a link between ER redox activity and calcium homeostasis, affecting microneme protein maturation, secretion, invasion, and replication.
- Redox-dependent calcium regulation in the ER influences the parasite's lytic cycle progression and may impact virulence, offering new insights into pathogenesis.