The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos - PubMed
4 hours ago
- #embryonic development
- #histone crotonylation
- #epigenetic reprogramming
- Histone crotonylation, particularly H3K18cr, is dynamically reprogrammed during mammalian gametes and early embryonic development.
- H3K18cr is highly enriched in sperm but nearly absent in mature oocytes, with maternal-biased asymmetry at the zygote stage that balances as development proceeds.
- Paternal and maternal H3K18cr occupy distinct genomic regions and have divergent biological functions.
- A transition from broad domains to narrow peaks of H3K18cr occurs at the minor zygotic genome activation (ZGA) stage, dependent on minor ZGA and essential for major ZGA and later development.
- Inhibition of HDAC1 complex impairs the broad-to-narrow transition, indicating cross-talk between histone crotonylation and acetylation in embryonic regulation.