Breakpoints in Alzheimer's disease biomarkers and cognition across the aging spectrum: The Mayo Clinic Study of Aging - PubMed
6 hours ago
- #Alzheimer's disease
- #biomarkers
- #aging
- The study identified age-related breakpoints in Alzheimer's disease biomarkers and cognition using data from 2082 participants in the Mayo Clinic Study of Aging.
- Breakpoints (age in years with 95% CI) were observed for GFAP (68.1), NfL (70.7), p-tau181 (67.2), amyloid PET (62.3), hippocampal volume (68.1), and global cognition (59.8), with tau PET showing no breakpoint.
- In a subset analyzed with mass-spectrometry, p-tau217 and p-tau181 broke at 72.6 years, while their ratios and Aβ42/40 did not show breakpoints.
- Breakpoints clustered around late midlife, suggesting potential windows for screening and monitoring in Alzheimer's disease progression.