Effects of daily multivitamin-multimineral and cocoa extract supplementation on epigenetic aging clocks in the COSMOS randomized clinical trial - PubMed
3 days ago
- #clinical trial
- #multivitamin supplementation
- #epigenetic aging
- Daily multivitamin-multimineral (MVM) supplementation modestly reduced the rate of increase in epigenetic aging clocks PCGrimAge and PCPhenoAge over 2 years.
- The effect of MVM on PCGrimAge was stronger in individuals with accelerated biological aging at baseline compared to those with normal or decelerated aging.
- Cocoa extract supplementation (500 mg cocoa flavanols per day) showed no significant effect on the five epigenetic aging clocks tested.
- The study involved 958 participants (482 women and 476 men) from the COcoa Supplement and Multivitamin Outcomes Study (COSMOS).
- The findings suggest potential benefits of MVM in slowing biological aging, but further research is needed to determine clinical relevance.