Longitudinal Analysis of Superoxide Dismutase 1 Seeding Activity in Amyotrophic Lateral Sclerosis Cerebrospinal Fluid - PubMed

4 hours ago

SOD1 seeding activity was detected in cerebrospinal fluid (CSF) of ALS patients, including those with and without SOD1 mutations, indicating misfolded SOD1 aggregates.
In ALS progression, SOD1 seeding activity correlated with clinical decline measured by ALSFRS-R slope and increased CSF neurofilament light levels.
SOD1 seeding activity was found early in the disease course in sporadic ALS patients, suggesting its potential as an early biomarker for clinical trial inclusion.
The study highlights the potential of SOD1 seeding activity as a diagnostic, prognostic, and pharmacodynamic biomarker for SOD1-targeting therapies like tofersen, which could benefit a broader ALS population.

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