Newcastle disease virus exploits Golgi stress and Golgiphagy to promote ferroptosis - PubMed
3 hours ago
- #Newcastle disease virus
- #ferroptosis
- #Golgi stress
- Ferroptosis, an iron-dependent lipid peroxidation cell death, is induced by Newcastle disease virus (NDV) through Golgi stress and Golgiphagy.
- NDV infection causes Golgi stress and selective degradation of ARF1 via autophagy, leading to reactive oxygen species accumulation and ferroptosis in tumor cells.
- Inhibition of Golgi stress with spermine reduces ferroptosis, showing antiviral and cytoprotective effects, highlighting therapeutic potential.