Diet-microbiome associations in 10,068 individuals from the Human Phenotype Project to guide personalized nutrition - PubMed
4 hours ago
- #personalized nutrition
- #microbiome
- #dietary patterns
- Diet significantly influences the human gut microbiome, affecting composition, diversity, and function.
- Study involved 10,068 participants from the Human Phenotype Project with app-based diet logs and shotgun metagenomics.
- Diet predicted microbial diversity (richness r = 0.26, Shannon Index r = 0.24) and the relative abundance of 669 out of 724 species tested.
- Specific food-microbe links identified, such as coffee with Lawsonibacter asaccharolyticus (r = 0.43) and yogurt with Streptococcus thermophilus (r = 0.42).
- Broader dietary patterns, especially food processing, predicted microbial diversity and composition.
- Diet-microbiome associations persist over four years, with 82.5% of species showing significant longitudinal tracking.
- Exploratory analysis developed for simulating personalized dietary interventions with predicted microbiome shifts linked to cardiometabolic health improvements.