RETN exacerbates sepsis by GBP5/NLRP3 signaling pathway-mediated pyroptosis of macrophage - PubMed
3 hours ago
- #RETN/GBP5/NLRP3 signaling
- #sepsis
- #macrophage pyroptosis
- RETN (resistin) is a key factor in sepsis initiation and development.
- RETN is primarily expressed in monocytes/macrophages and is upregulated in septic patients.
- RETN overexpression upregulates GBP5 and NLRP3, leading to macrophage pyroptosis.
- Knockdown of RETN or GBP5 mitigates macrophage pyroptosis and reduces organ damage in sepsis.
- The RETN/GBP5/NLRP3 signaling axis is a potential target for sepsis treatment.