A human iPSC model of tauopathies engineered for 4R tau isoform expression endogenously develops late-stage neuronal tau pathology - PubMed
4 hours ago
- #iPSC model
- #tauopathy
- #neurodegenerative disease
- Researchers developed a human iPSC model engineered to express the adult brain-specific 4R tau isoform, enabling cell-intrinsic formation of late-stage tauopathy hallmarks without exogenous tau.
- The model demonstrated accumulation of seeding-competent, hyperphosphorylated tau in tangle-like structures, with exclusive mutant 4R expression intensifying pathology.
- It serves as a translational platform for testing chemical modulators and tau PET tracers, supporting drug development and mechanistic studies of tauopathies.