A U-Shaped Association Between Blood mtDNA Copy Number and Risk of Type 2 Diabetes - PubMed
4 hours ago
- #Cohort Study
- #mtDNA
- #Type 2 Diabetes
- A U-shaped association was found between blood mtDNA copy number (CN) and the risk of type 2 diabetes, particularly in younger individuals.
- The study included 34,835 adults from the KARE cohort and 289,338 from the UK Biobank (UKB).
- In the KARE cohort, hazard ratios showed a U-shaped trend across mtDNA-CN quartiles, while UKB exhibited an inverse linear trend.
- Age-stratified analyses revealed the U-shaped association was more evident in younger participants (aged <65 in KARE, <50 in UKB).
- mtDNA-CN levels declined with age, with an accelerated decrease beyond 65 years in KARE and 50 years in UKB.
- The study was funded by multiple national research programs in China.