Xanthoxylin alleviates dextran sulfate sodium (DSS)-induced colitis by targeting macrophage infiltration via the tumor necrosis factor (TNF) /nuclear factor-kappa B (NF-κB) signaling pathway - PubMed
9 hours ago
- #macrophage infiltration
- #anti-inflammatory
- #ulcerative colitis
- Xanthoxylin (XT) alleviates DSS-induced colitis by targeting macrophage infiltration via the TNF/NF-κB signaling pathway.
- XT, isolated from Zanthoxylum spp., shows anti-inflammatory effects by reducing pro-inflammatory cytokines and restoring the intestinal mucosal barrier.
- Mechanistically, XT suppresses colonic lamina propria macrophage infiltration, particularly the F4/80loCD11b+ subset, and stabilizes tight junctions in vitro.
- The study highlights XT's potential as a therapeutic agent for ulcerative colitis (UC).