LINE-1 retrotransposition modulates metabolic stress and promotes cuproptosis resistance in lung squamous cell carcinoma by disrupting mitochondrial membrane homeostasis - PubMed
4 hours ago
- #LINE-1 Retrotransposition
- #Mitochondrial Dysfunction
- #Cuproptosis Resistance
- LINE-1 retrotransposition modulates metabolic stress and promotes cuproptosis resistance in lung squamous cell carcinoma.
- The study reveals that LINE-1 retrotransposition disrupts mitochondrial membrane homeostasis, contributing to cuproptosis resistance.
- Ethics approval was obtained from Tianjin Medical University, and animal experiments followed AAALAC and IACUC guidelines.
- The authors declare no competing interests.
- References include key studies on lung squamous cell carcinoma, signaling pathways, and mitochondrial dysfunction.