STING signaling modulation by COPII cargo recognition - PubMed
3 hours ago
- #ER exit mechanism
- #STING signaling
- #COPII trafficking
- STING activation requires COPII-mediated ER exit, with the EExxx motif identified as the ER-exit motif recognized by SEC24C.
- AlphaFold3 predicted structure shows SEC24C binding to a STING dimer, revealing the EExxx motif in a previously unresolved region; mutations disrupt trafficking and signaling.
- The EExxx motif is conserved, suboptimal to prevent immune overactivation, and can be engineered for enhanced antitumor immunity or to inhibit endogenous signaling.